ABSTRACT
Five healthy adult male Iranian donkeys [Equus asinus] were selected and Ivermectin [0.2,0.6 and 0.9 mg/kg, orally at different times] for 14 days was administered. Before dosing, control blood samples were taken on day 0. Blood samples were taken on days 1,2,3,7 and 14 following ivermectin administration at different doses. The results showed that the activity of serum AST and LDH increased on days 7 and 14 following ivermectin [0.2, 0.6 and 0.9 mg/kg, orally] administration [p<0.05]. ALP activity and BUN concentration increased significantly on day 14 following ivermectin [0.2, 0.6 and 0.9 mg/kg, orally] administration [p<0.05]. Changes of ablumin, creatinin,glucose, total protein, Phosphorous and calcium concentrations and hemoglobin, PCV, MCH, MCHC, MCV and percentages of neutrophils, eosinophils, monocytes, lymphocytes and platelet numbers were not significant [p>0.05]. As it was shown in short term, no abnormal clinical and laboratory findings were detected following different oral doses of ivermectin and it seems that the drug can be safely administered to this species